Award
NIH Reporter #5R01GM032238-38
Structure and Function of a Eukaryotic Centromere
Recipient
UNIV OF NORTH CAROLINA CHAPEL HILL
Award Amount
$527,794.00
Ceiling
$527,794.00
Awarded
February 24, 2025
Identifier
5R01GM032238-38
Research project funded by NIGMS to study the structure and function of eukaryotic centromeres using computational and bioimaging methods, aiming to understand chromosome segregation mechanisms.
Description
This project focuses on understanding the physical and biological properties of centromeres, which are crucial for chromosome segregation during cell division. The research involves developing computational tools and bioimaging techniques to study the structure and dynamics of pericentromeric DNA in yeast and other organisms. The study aims to elucidate how centromere DNA is organized into a spring-like structure that resists microtubule pulling forces, with potential implications for understanding chromosome behavior across phylogeny.