Award
National Cancer Institute 5R01CA266404-05
Resistance mechanisms to autophagy-modulating therapies
Recipient
University of Pennsylvania
Award Amount
$654,478.00
Ceiling
$654,478.00
Awarded
January 19, 2026
Identifier
5R01CA266404-05
Research project awarded by the National Cancer Institute to study resistance mechanisms to autophagy-modulating therapies in melanoma and other cancers, with a focus on lipid raft assembly and therapeutic strategies in patient-derived models.
Description
The project focuses on understanding resistance mechanisms to autophagy-modulating therapies in melanoma and other cancers. The research involves defining mechanisms of lipid raft assembly and testing therapeutic strategies in patient-derived xenograft models. The project aims to identify new therapeutic vulnerabilities and combinations for future clinical trials.