Award
National Cancer Institute 5R37CA288577-03
Leveraging Biologically Specific PET/MRI Monitoring and Therapeutic Modulation of the Hypoxic Glioblastoma Tumor Immune Microenvironment into Improved Outcomes
Recipient
Oregon Health & Science University, Portland, OR
Award Amount
$541,069.00
Ceiling
$541,069.00
Awarded
May 04, 2026
Identifier
5R37CA288577-03
This NIH-funded project focuses on developing and validating a biologically specific imaging method to monitor and modulate the hypoxic tumor immune microenvironment in glioblastoma, aiming to improve treatment outcomes through advanced PET/MRI imaging and therapeutic strategies.
Description
The project aims to use novel iron nanoparticle enhanced 18F-fluoromisonidazole PET/MRI derived Segregation and Extravascular Localization of Ferumoxytol Imaging (SELFI) hypoxic fraction to quantitatively determine how hypoxia and TAM-based neuroinflammation relate to treatment sensitivity in glioblastoma. The goal is to improve treatment outcomes by monitoring and therapeutically modulating the hypoxic tumor immune microenvironment.