Award
National Heart, Lung, and Blood Institute 5R01HL175577-02
"Outside-in” Model of Cardiac Pacemaking: Extracellular Mediated Automaticity
Recipient
University of North Carolina Chapel Hill, Department of Physiology, Chapel Hill, NC, United States
Award Amount
$680,708.00
Ceiling
$680,708.00
Awarded
May 20, 2026
Identifier
5R01HL175577-02
Research project funded to study cardiac pacemaking mechanisms focusing on extracellular ionic fluctuations in the sinoatrial node.
Description
The project aims to test a novel model of sinoatrial node (SAN) function to understand the mechanisms underlying cardiac pacemaking and SAN dysfunction. It focuses on extracellular ionic fluctuations, particularly potassium ion dynamics, and their role in rhythmic impulse generation in the SAN.