Award
National Institute of Dental and Craniofacial Research 5R01DE030123-06
Role of CRTC1-MAML2 in Salivary Mucoepidermoid Carcinoma Pathobiology
Recipient
H. Lee Moffitt Cancer Center & Research Institute
Award Amount
$498,468.00
Ceiling
$498,468.00
Awarded
May 01, 2025
Identifier
5R01DE030123-06
This award supports research on the role of the CRTC1-MAML2 fusion oncogene in the development and progression of salivary mucoepidermoid carcinoma, aiming to improve understanding and therapeutic interventions.
Description
The proposal aims to investigate how the CRTC1/MAML2 (C1/M2) fusion oncogene regulates differentiation and tumor grade in salivary MEC, focusing on its interaction with CREB and MYC transcriptional networks, and to develop models and tools for longitudinal tumorigenesis study.