Award
National Institute of Neurological Disorders and Stroke 5R21NS139100-02
Investigating Dysfunction of Neuroimmune-Related Processes in Models of ALS/FTD TDP-43
Recipient
University of Massachusetts Medical School Worcester, Worcester, MA, United States
Award Amount
$209,375.00
Ceiling
$209,375.00
Awarded
March 31, 2026
Identifier
5R21NS139100-02
This award funds research to understand how TDP-43 dysfunction affects neuroimmune processes in ALS and FTD, using advanced models to explore innate immunity and microglial roles in disease progression and response to brain injury.
Description
Research project investigating the link between traumatic brain injury and neurodegeneration focusing on ALS and FTD with TDP-43 pathology, using mouse models and human induced pluripotent stem cell derived microglia to study innate immune pathways and microglial function.