Award
National Institute on Drug Abuse 5R01DA059640-03
Craving-based Digital Phenotyping During MOUD Treatment
Recipient
University of Massachusetts Medical School Worcester, Worcester, MA
Award Amount
$791,682.00
Ceiling
$791,682.00
Awarded
July 13, 2026
Identifier
5R01DA059640-03
This NIH-funded project by the University of Massachusetts Medical School focuses on using wearable sensors to develop digital biomarkers and phenotypes for opioid use disorder treatment, aiming to improve personalized treatment and recovery outcomes.
Description
The project aims to validate digital biomarkers of craving during medication for opioid use disorder (MOUD) using wearable sensors. It seeks to describe craving trajectories, identify disease subtypes based on physiological and clinical data, and develop digital phenotypes to predict treatment responsiveness. The study involves a prospective observational trial of 300 participants initiating treatment with buprenorphine, methadone, or naltrexone, monitored over approximately 60 days with passive wearable sensor data collection. The goal is to enhance personalized treatment strategies, improve efficacy, and support sustained recovery through digital health tools.