Award
National Heart, Lung, and Blood Institute 5K08HL171936-02
Mechanisms of Complement Activation in Traumatic Injury
Recipient
University of Nebraska Medical Center, Omaha, NE, United States
Award Amount
$166,644.00
Ceiling
$166,644.00
Awarded
August 14, 2025
Identifier
5K08HL171936-02
Research project funded by NIH to study complement system activation after traumatic injury and its role in organ failure, aiming to develop anti-complement therapies.
Description
This research focuses on understanding how the complement system, a key inflammatory pathway, gets activated after trauma and contributes to organ failure and mortality. The project involves biomarker analysis in human plasma, in vitro endothelial cell models, and mouse models deficient in complement proteins C3 and C5 to elucidate mechanisms and evaluate therapeutic targets. The findings aim to inform potential anti-complement therapies for trauma patients.