Award
National Institute of General Medical Sciences 5R35GM133359-07
Protein structure and dynamics in ultra-heterogeneous environments-Renewal
Recipient
University of Texas at Austin
Award Amount
$386,526.00
Ceiling
$386,526.00
Awarded
June 03, 2026
Identifier
5R35GM133359-07
The award supports research on protein structure and dynamics in complex cellular-like environments, focusing on hydrogen bonding, biocondensate interactions, and protein-polymer conjugation to improve understanding and therapeutic design.
Description
This project seeks to characterize the driving forces behind protein structure and dynamics in environments that mimic the cytosol, including quantifying the impact on the solvation shell of biomolecules, linking changes in hydrogen-bond environment with protein structure and stability, advancing 2D IR spectroscopic techniques for in-cell measurements, investigating liquid-liquid phase separation biocondensate structure and dynamics, and exploring protein-polymer interactions for biologics design.