Award
National Institute of Allergy and Infectious Diseases 5R01AI175212-03
Role of T-bet B cells in rheumatoid arthritis
Recipient
University of Rochester
Award Amount
$711,221.00
Ceiling
$711,221.00
Awarded
December 23, 2025
Identifier
5R01AI175212-03
The award funds research on the role of T-bet expressing B cells in rheumatoid arthritis, focusing on their contribution to inflammation and bone erosion, with the goal of developing targeted therapies to prevent bone damage and achieve lasting remission.
Description
This project evaluates how a novel subset of B cells, expressing the transcription factor T-bet, contribute to ongoing disease activity, inhibit bone-forming osteoblasts, and activate bone-eroding osteoclasts, contributing to inflammation and joint destruction in rheumatoid arthritis. The research aims to define how T-bet influences synovial B cell states, mediates B cell-driven bone effects, and coordinates pathogenic functions in RA target tissue.