Award
NIH Reporter #5R01EY034503-04
Cellular Mechanisms of State-Dependent Processing in Visual Cortex
Recipient
University of Connecticut Storrs, Mansfield, CT, USA
Award Amount
$402,500.00
Ceiling
$402,500.00
Awarded
August 27, 2026
Identifier
5R01EY034503-04
Research project funded by the National Eye Institute to study cellular mechanisms of visual processing changes across brain states, using rabbit models to understand impacts on perception and safety.
Description
The proposed research investigates how information processing in the visual system changes as brain states shift from alert to drowsy and sleep. It aims to understand the cellular mechanisms driving these state-dependent changes and their impact on visual perception. The study will utilize intracellular and extracellular recordings from visual cortex (V1) and thalamus (LGN) in rabbits, analyzing responses during natural transitions between alert, drowsy, and sleep states. The research will provide insights into how brain states influence visual responses and perception, with implications for preventing drowsy driving accidents and understanding cognitive disorders.