Award
National Heart, Lung, and Blood Institute 5R01HL180520-02
Novel Roles for IRE1 in Regulating Cardiac Fibrosis
Recipient
National Heart Lung and Blood Institute (NHLBI)
Award Amount
$717,520.00
Ceiling
$717,520.00
Awarded
July 21, 2026
Identifier
5R01HL180520-02
NIH grant awarded to study the molecular mechanisms of cardiac fibrosis and heart failure, focusing on IRE1's role, using mouse models and cardiac fibroblasts.
Description
The project aims to decipher the molecular mechanisms contributing to cardiac fibrosis and heart failure, focusing on the role of the UPR and IRE1. The project involves mechanistic studies in mouse models and primary cardiac fibroblasts. It includes specific aims to determine transcriptomic profiles, functional significance of Tmem100 degradation, and therapeutic efficacy of small molecule activators.