National Cancer Institute 1R37CA302677-01A1

Radiation synthetic combinations in high-risk Ewing sarcoma

NIH grant awarded to Mayo Clinic Rochester for research on improving radiation therapy in high-risk Ewing sarcoma by studying genetic vulnerabilities and immune response, aiming to develop new combination treatments.

Description

This project aims to better understand mechanisms to reverse immunoprotection during radiation therapy in adolescent cancer Ewing sarcoma, focusing on tumors with loss of STAG2 protein. The goal is to develop multi-modality treatments to enhance radiation therapy effectiveness and translate findings into new patient treatments. The research involves in vitro analyses, in vivo tumor modeling, and human specimen analyses, including single-cell RNA sequencing, ATAC-seq, and spatial transcriptomics. The study will test therapies in humanized and NSG mice, with collaboration from experts in radiation oncology, sarcoma biology, epigenetics, and bioinformatics.

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