Award
NIH Reporter #5K23HD119673-02
Neurocognitive Outcomes and the Trajectory of Recovery One-year After Pediatric Sepsis
Recipient
Children's Hospital of Philadelphia
Award Amount
$155,432.00
Ceiling
$155,432.00
Awarded
July 07, 2026
Identifier
5K23HD119673-02
A research project funded by NICHD to study neurocognitive outcomes and recovery trajectories in children after sepsis, focusing on brain dysfunction and medication exposure effects.
Description
This study aims to determine the prevalence of new neurocognitive morbidities up to 12 months post-discharge in pediatric sepsis survivors, assess the trajectory of recovery, and explore the association of high anticholinergic exposures during sepsis with brain dysfunction. The study involves 180 school-aged sepsis survivors, with neurocognitive assessments at multiple time points, including caregiver-reported measures and formal neuropsychological evaluations.