Award
National Institute of Allergy and Infectious Diseases 1R21AI196856-01
Post-initiation control of Pseudomonas aeruginosa exopolysaccharide biosynthesis operons
Recipient
Ohio State University, Columbus, OH, United States
Award Amount
$439,094.00
Ceiling
$439,094.00
Awarded
April 01, 2026
Identifier
1R21AI196856-01
The award funds research on transcription regulation in Pseudomonas aeruginosa, specifically the control of exopolysaccharide biosynthesis operons, to understand bacterial biofilm formation and resistance mechanisms.
Description
This project investigates the regulation of RNA chain elongation in Pseudomonas aeruginosa, focusing on the pel and psl operons, to understand mechanisms of transcription termination and antitermination involving Rho, NusG, and Mva proteins. The research aims to elucidate post-initiation transcription control in P. aeruginosa, involving in vivo RNA probing and in vitro assays, potentially providing insights into bacterial pathogenesis and therapeutic targets.