Award
National Institute of General Medical Sciences 5P20GM125528-07
The role of B cell estrogen signaling in menopause-associated metabolic dysfunction
Recipient
University of Oklahoma Health Sciences Center
Award Amount
$257,400.00
Ceiling
$257,400.00
Awarded
June 30, 2026
Identifier
5P20GM125528-07
The award supports research on the role of B cell estrogen signaling in metabolic dysfunction associated with menopause, aiming to uncover immune mechanisms driving adipose tissue expansion and metabolic disease in aging women.
Description
This project investigates how loss of estrogen receptor alpha signaling in B cells contributes to weight gain, adipose tissue expansion, metabolic dysfunction, and systemic inflammation during perimenopause and menopause. The study uses mouse models to determine the effects of declining estrogen on B cell phenotype and infiltration into adipose tissue, and how this influences weight gain and metabolic health.