Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5F31AR083722-02
The effect of genetic variation on mRNA splicing in chondrocytes responding to cartilage matrix damage
Recipient
University of North Carolina at Chapel Hill
Award Amount
$41,355.00
Ceiling
$41,355.00
Awarded
June 16, 2025
Identifier
5F31AR083722-02
NIH grant awarded to study the impact of genetic variation on mRNA splicing in chondrocytes related to cartilage damage and osteoarthritis risk, integrating genetic data to identify disease-relevant variants and potential therapeutic targets.
Description
This project aims to identify how genetic variants influence mRNA splicing in chondrocytes, which respond to cartilage matrix damage, contributing to osteoarthritis risk. The study will analyze differential splicing events, identify splicing QTLs, and integrate findings with GWAS data to discover disease-relevant variants and genes.