Award
National Human Genome Research Institute 5R01HG012367-04
Sequence-based Machine Learning for Inference of Dynamic Cell State Gene Network Models
Recipient
Johns Hopkins University
Award Amount
$449,094.00
Ceiling
$449,094.00
Awarded
April 14, 2025
Identifier
5R01HG012367-04
NIH grant awarded to Johns Hopkins University to develop machine learning models for gene network inference related to enhancer perturbation and regulatory element function, aiming to improve understanding of gene regulation and disease impact.
Description
Development of improved sequence-based machine learning models to build gene network models to predict the impact of enhancer perturbation by CRISPR or genetic variation, focusing on embryonic stem cell to definitive endoderm system and large consortium datasets.