Award
NIH Reporter #1R01ES038763-01
Impact of an Air Purification Intervention on Biological Aging and Molecular Signatures of Improved Cardiometabolic Health in High-Risk Older Adults
Recipient
Stanford University
Award Amount
$850,689.00
Ceiling
$850,689.00
Awarded
August 13, 2026
Identifier
1R01ES038763-01
A randomized controlled trial to assess the impact of HEPA air filters on biological aging and cardiometabolic health markers in older adults with eosinophilic COPD.
Description
This project aims to evaluate the hypothesized causal relationship between an in-home high-efficiency particulate air (HEPA) filter intervention and key molecular characteristics in multiple target tissues, as well as clinical indicators of cardiopulmonary health, in older adults with eosinophilic COPD. The project leverages data and samples already collected at baseline and during follow-up in a NIEHS-funded, double-blinded, randomized controlled trial placing HEPA filters vs sham in the homes of 178 former smokers with eosinophilic COPD for 12 months.