Award
National Institute of General Medical Sciences 5R35GM155058-02
Probing protein structure and aggregation in complex environments with 2D IR spectroscopy
Recipient
Vanderbilt University, Nashville, TN, United States
Award Amount
$395,943.00
Ceiling
$395,943.00
Awarded
August 07, 2025
Identifier
5R35GM155058-02
This award supports research developing advanced spectroscopic techniques to study protein structure and aggregation in complex environments, with applications to neurodegenerative diseases such as Alzheimer's. It involves the use of unnatural amino acids, 2D IR spectroscopy, and machine learning to understand protein interactions and nanoparticle effects.
Description
The research aims to develop spectroscopic methods to gain insight into protein structure and dynamics in complex environments impacting human health. It focuses on advancing the use of unnatural amino acids (UAAs) and two-dimensional infrared (2D IR) spectroscopy to study protein interactions and aggregation, particularly using β-amyloid in cerebrospinal fluid as a model. The project also investigates nanoparticle-protein interactions and employs machine learning to enhance spectral resolution.