Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK099076-17
Role of innate immunity and the microbiome in colitis associated dysplasia
Recipient
Cedars-Sinai Medical Center
Award Amount
$517,163.00
Ceiling
$517,163.00
Awarded
April 13, 2026
Identifier
5R01DK099076-17
This NIH-funded research project studies how innate immunity and the microbiome contribute to colitis-associated dysplasia, particularly through the enzyme DUOX2 and its role in epithelial barrier dysfunction and tumor-promoting mechanisms.
Description
The project investigates the role of innate immune signaling and gut microbiota in the development of dysplasia in ulcerative colitis (UC) patients, focusing on the enzyme DUOX2 and its effects on epithelial barrier dysfunction and tumorigenesis.