Award
National Eye Institute 5R21EY036998-02
Anticodon Engineered tRNA for the Treatment of Hereditary Eye Disease
Recipient
University of Iowa
Award Amount
$187,260.00
Ceiling
$187,260.00
Awarded
January 23, 2026
Identifier
5R21EY036998-02
NIH grant awarded to University of Iowa for developing gene therapy using engineered tRNA to treat hereditary eye diseases caused by nonsense mutations, with research conducted in mouse models.
Description
This project explores a novel therapy using engineered suppressor tRNA molecules, specifically Arg-TGA ACE-tRNA, to bypass premature termination codons (PTCs) and restore normal protein function in ocular tissues. The study will assess the efficacy, safety, and cellular activity of this approach in transgenic mouse models, aiming to provide sustained correction of PTC mutations and evaluate potential biological impacts.