Award
National Institute of General Medical Sciences 5R35GM142421-05
Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors
Recipient
University of North Texas
Award Amount
$360,055.00
Ceiling
$360,055.00
Awarded
August 07, 2025
Identifier
5R35GM142421-05
This NIH grant supports research to develop genetic sensors and circuits to engineer novel cellular behaviors for biomedical applications, including monitoring toxic pollutants.
Description
The project aims to advance the capability to engineer organisms for biomedical uses by developing genetic sensors and circuits. Specific objectives include establishing design principles for engineering regulators from different protein families, creating extensive genetic sensors for detecting signals, and designing novel genetic circuits to address biomedical challenges. The research involves modular biosensors based on regulators in the LacI and TetR families, hybrid regulators, and cellular devices for monitoring toxic pollutants in food and water.