Award
National Institute of General Medical Sciences 1R35GM160352-01
Myeloid-Derived Suppressor Cells in Immunological Endotyping and Intervention of Chronic Critical Illness after Sepsis
Recipient
University of Florida, Gainesville, FL
Award Amount
$422,125.00
Ceiling
$422,125.00
Awarded
August 22, 2025
Identifier
1R35GM160352-01
Research project funded by NIGMS to study immune response heterogeneity in sepsis using multi-omics and AI to improve diagnostics and therapeutics for chronic critical illness.
Description
The project aims to assess whether multi-omic data of MDSCs can improve sepsis endotyping and predict clinical trajectories better than static measurements, delineate the longitudinal interaction between MDSCs and T cells, and identify potential drugs for intervention from FDA-approved options. This will be achieved through integrative analysis of transcriptomics, chromatin accessibility, DNA methylation, metabolomics, and clinical data, leveraging AI and statistical models.