Award
NIH Reporter #5F32NS134683-03
A Comparative Analysis of OPC and Microglia Phagocytosis and its Relevance to Neurodegenerative Disease
Recipient
University of Massachusetts Medical School Worcester, Worcester, MA, United States
Award Amount
$73,769.00
Ceiling
$73,769.00
Awarded
May 05, 2026
Identifier
5F32NS134683-03
This project investigates OPC and microglia phagocytosis, its impact on OPC differentiation, and the role of complement C3 in neurodegeneration, aiming to challenge existing paradigms and inform therapeutic development.
Description
The project aims to understand OPC phagocytosis in health and disease, comparing it to microglia, and its impact on OPC differentiation, especially in neurodegenerative conditions like multiple sclerosis. It involves in vitro and in vivo assays, live cell imaging, and analysis of complement C3 dependence.