Award
National Heart, Lung, and Blood Institute 1R01HL174545-01A1
Roles for SGK1 in Cardiometabolic Heart Failure with Preserved Ejection Fraction
Recipient
Utah State Higher Education System--University of Utah
Award Amount
$654,530.00
Ceiling
$654,530.00
Awarded
July 23, 2025
Identifier
1R01HL174545-01A1
The award funds research on the molecular mechanisms of cardiometabolic heart failure with preserved ejection fraction, targeting SGK1 to develop new therapies for this condition and related obesity diseases.
Description
This project aims to decipher the molecular mechanisms contributing to heart failure with preserved ejection fraction (HFpEF), focusing on the role of serum glucocorticoid kinase 1 (SGK1) in cardiac pathology and systemic metabolic dysfunction. The goal is to develop novel and selective therapeutic avenues for intervention to reduce mortality from cardiovascular disease and associated obesity-related diseases.