Award
NIH Reporter #5R01NS136342-02
Long distance regressive signaling underlies sculpting of the nervous system during development.
Recipient
Vanderbilt University, Nashville, TN
Award Amount
$528,712.00
Ceiling
$528,712.00
Awarded
January 14, 2026
Identifier
5R01NS136342-02
This award funds research on the cellular and molecular mechanisms of long-distance regressive signaling in nervous system development, aiming to understand neurodegenerative diseases like ALS and Alzheimer's.
Description
Elucidating the cellular and molecular mechanisms that underlie long-distance regressive signaling, which regulates neuronal death and axon degeneration, presents a novel perspective on nervous system patterning. The proposed research carries substantial significance, as the insights gained will enhance our understanding of the etiology and progression of pathologies that negatively impact the nervous system's structure, such as Amyotrophic Lateral Sclerosis (ALS) and Alzheimer's disease.