Award
NIH Reporter #11440538
JAK/STAT signaling as a therapeutic target to mitigate long-term effects of acute organophosphate intoxication
Recipient
University of California at Davis
Award Amount
$468,559.00
Ceiling
$468,559.00
Awarded
August 20, 2026
Identifier
11440538
NIH grant awarded to University of California at Davis to study JAK/STAT signaling as a therapeutic target for mitigating long-term neurological effects of acute organophosphate intoxication, led by Amy R. Brooks-Kayal.
Description
This is a NIH grant project focused on neuroinflammation and epileptogenesis related to organophosphate poisoning. The project involves testing the efficacy of JAK/STAT pathway inhibitors, specifically ruxolitinib, in mitigating long-term neurological effects. The project is led by Amy R. Brooks-Kayal, Professor and Chair, Department of Neurology at UC Davis. The project aims to establish STAT3 as a key driver of neurotoxicity and to develop countermeasures for chemical threats.