Award
John E. Fogarty International Center for Advanced Study in the Health Sciences 5K43TW012801-02
Informing optimal dosing of the future antimalarial, artemether-lumefantrine plus amodiaquine, in key neglected target populations of children with severe acute malnutrition and adults living with HIV
Recipient
Kamuzu University of Health Sciences, Blantyre, Malawi
Award Amount
$108,804.00
Ceiling
$108,804.00
Awarded
September 14, 2025
Identifier
5K43TW012801-02
Award to Dr. Clifford George Banda to study pharmacokinetics and safety of artemether-lumefantrine plus amodiaquine in children with severe acute malnutrition and adults with HIV to optimize dosing and improve malaria treatment outcomes.
Description
This award will allow Dr. Clifford George Banda to characterise the pharmacokinetic and safety profiles of two long-acting artemisinin partner drugs, lumefantrine and amodiaquine, and their active metabolites when administered as artemether-lumefantrine plus amodiaquine (ALAQ) in African young children with uncomplicated severe acute malnutrition as well as adults living with HIV and on dolutegravir-based antiretroviral therapy. The project aims to optimize dosing of antimalarial drugs in vulnerable populations to combat resistance and improve treatment outcomes in Africa.