National Institute of Allergy and Infectious Diseases 1R01AI191274-01A1

Defining virulence factor functions using minimal pathogen genomes

NIH grant awarded to UT Southwestern Medical Center to study bacterial virulence factors in Salmonella enterica using advanced imaging and murine models, aiming to discover new pathogenic mechanisms and therapeutics.

Description

This project aims to elucidate the functions of bacterial virulence factors using minimal pathogen genomes, focusing on Salmonella enterica. The research involves understanding how bacterial effector proteins regulate the phago-lysosomal vacuole, bacterial binary fission, and host membrane division. The study will utilize single molecule tracking, live cell imaging, and murine models to investigate effector-host interactions, particularly targeting a Rab-family GTPase defense system. The goal is to identify new mechanisms of bacterial pathogenicity and develop targeted therapeutics.

View original record