Award
National Institute on Aging 5R01AG076956-05
Neural stem cell rejuvenation through single cell pharmacogenomics
Recipient
University of Southern California, Los Angeles, CA
Award Amount
$738,890.00
Ceiling
$738,890.00
Awarded
February 23, 2026
Identifier
5R01AG076956-05
A NIH-funded project by the University of Southern California to develop pharmacogenomics methods to rejuvenate neural stem cells and improve cognition in aging and Alzheimer's disease, with a $738,890 award from the National Institute on Aging.
Description
This research aims to develop computational network and pharmacogenomics approaches to prioritize and modulate key age-related changes for neural stem cell (NSC) rejuvenation to improve cognition and discover new anti-aging therapies. The study will provide evidence of NSC rejuvenation and demonstrate the utility of new single cell pharmacogenomics and gene networks for enhancing neurogenesis in the aged hippocampus, potentially shifting paradigms in NSC capacity for regeneration and cognitive reserve building.