Award
NIH Reporter #1R35GM165612-01
Molecular determinants of lipid-protein recognition
Recipient
University of California, San Diego, La Jolla, CA
Award Amount
$384,394.00
Ceiling
$384,394.00
Awarded
July 13, 2026
Identifier
1R35GM165612-01
Award for research on lipid-protein interactions using advanced computational and experimental methods to understand cellular processes and disease mechanisms, specifically Niemann-Pick Disease Type C.
Description
This project investigates the biophysical interactions of lipid headgroups with membrane-associated proteins, focusing on their role in cellular homeostasis and disease. It employs deep learning, molecular dynamics, and de novo protein design to model and predict protein-lipid interactions, with a specific focus on the lipid GM2 and its role in Niemann-Pick Disease Type C.