Award
Children's Hospital of Philadelphia 5DP5OD036159-03
Unlocking microglia targeting for neurotherapeutics
Recipient
Children's Hospital of Philadelphia
Award Amount
$445,000.00
Ceiling
$445,000.00
Awarded
July 28, 2025
Identifier
5DP5OD036159-03
Award for research on microglia targeting for neurotherapeutics involving gene editing and antiviral immunity, funded by NIH.
Description
This project aims to identify and overcome microglia restriction factors to enable gene editing with lentiviruses and gain insights into microglia-mediated antiviral immunity. It involves CRISPR knockout screening, in vivo validation, and the development of microglia-targeted AAVs. The project is funded by NIH and is part of the RFA-RM-22-021 initiative.