Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 1K99AR081926-01A1
Consequence of human satellite repeat expression and immunostimulatory potential in FSHD
Recipient
FRED HUTCHINSON CANCER CENTER
Award Amount
$124,308.00
Ceiling
$124,308.00
Awarded
September 09, 2025
Identifier
1K99AR081926-01A1
Research project funded by NIAMS to study the role of HSATII RNA in the pathogenesis of FSHD, focusing on molecular mechanisms and potential biomarkers for diagnosis and therapy.
Description
Facioscapulohumeral muscular dystrophy (FSHD) is caused by mis-expression of DUX4, leading to activation of embryonic transcriptional programs and repetitive sequences. This project aims to understand the role of HSATII RNA in FSHD pathogenesis, focusing on the formation of ribonucleoprotein complexes and regulatory mechanisms.