Award
NIH Reporter #1R01DK146271-01A1
Understanding and exploiting muscle and liver contributions to RNA-Nanoparticle immunity
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY, USA
Award Amount
$742,478.00
Ceiling
$742,478.00
Awarded
July 16, 2026
Identifier
1R01DK146271-01A1
This NIH-funded project aims to understand the role of muscle and liver cells in RNA-LNP immunity to improve RNA-based vaccines and therapeutics by modulating immune responses.
Description
The objective of this study is to gain mechanistic insight into how RNA-LNP expression in muscle and liver influences immunity, with the goal of establishing RNA designs that can boost immunity or tolerance to mRNA payloads.