Award
National Heart, Lung, and Blood Institute 5R01HL153164-06
TNFR1 Expressing Exosomes are Critical Mediators of Pathological Immune Activation in the Spleen post-Myocardial Infarction
Recipient
PENNSYLVANIA STATE UNIV HERSHEY MED CTR
Award Amount
$550,936.00
Ceiling
$550,936.00
Awarded
September 08, 2025
Identifier
5R01HL153164-06
This NIH-funded research project studies how exosomes expressing TNFR1 contribute to immune activation and cardiac dysfunction after myocardial infarction, focusing on the spleen's involvement and the molecular mechanisms of exosomal TNFR1.
Description
Research project investigating the role of exosomal TNFR1 in mediating immune activation and cardiac dysfunction following myocardial infarction. The study aims to determine the spleen's role in exosomal processing post-MI, define the source and role of vesicular TNFR1, and assess its role in immunogenic signaling.