Award
National Institute of Neurological Disorders and Stroke 1RF1NS136108-01
Cellular Mechanisms and Therapeutic Potential of NR4A1 in Pain Resolution
Recipient
University of Cincinnati
Award Amount
$2,103,564.00
Ceiling
$2,103,564.00
Awarded
May 28, 2024
Identifier
1RF1NS136108-01
This project explores NR4A1's role in resolving pain and aims to develop non-addictive therapies targeting NR4A1 for pain conditions linked to opioid abuse. It includes testing FDA-approved NR4A1 agonists and identifying biomarkers for pain resolution.
Description
The study investigates the role of NR4A1 in pain resolution, aiming to validate NR4A1 as a non-addictive therapeutic target for postoperative and low back pain, conditions at high risk of opioid abuse. It will also identify SPP1 as a biomarker for pain resolution and test NR4A1 agonists.