Award
NIH Reporter #1R01AG100367-01
Illuminating Reactive Astrocyte Contributions to Alzheimer’s Pathology via PIP-sort Technology
Recipient
University of California, San Francisco
Award Amount
$700,564.00
Ceiling
$700,564.00
Awarded
September 17, 2026
Identifier
1R01AG100367-01
A National Institute on Aging award to develop and apply PIP-sort technology for studying reactive astrocytes and their contribution to Alzheimer’s disease.
Description
The project develops and applies PIP-sort, a droplet digital PCR-based method to isolate and analyze rare reactive astrocyte nuclei from frozen brain samples. It will validate the method, use it for transcriptomic and epigenomic profiling, and investigate reactive astrocytes’ roles in Alzheimer’s disease pathology.