Award
NIH Reporter #1K01AA033159-01
Investigating Oleoylethanolamide (OEA) as a Novel Multi-System Based Therapeutic for Young Adults with Alcohol Use Disorder
Recipient
Medical University of South Carolina
Award Amount
$195,912.00
Ceiling
$195,912.00
Awarded
July 24, 2026
Identifier
1K01AA033159-01
A clinical trial funded by NIH to test OEA as a therapeutic for young adults with alcohol use disorder, focusing on multi-system effects and alcohol use reduction.
Description
This pilot clinical trial will evaluate the potential of oleoylethanolamide (OEA), a naturally occurring endocannabinoid-like lipid, to modulate brain, immune, and microbiome systems and reduce alcohol use behaviors in young adults with alcohol use disorder (AUD). The study involves a randomized, double-blind, placebo-controlled trial with 42 young adults aged 18-25, assessing effects of 6 weeks of OEA supplementation on peripheral inflammation, oral microbiome composition, neurocognitive function, and alcohol use outcomes.