Award
National Institute on Aging 5R01AG076932-05
Development of novel genomic approaches for profiling cellular temporal-spatial dynamics of neurogenesis in Aging and Alzheimer's disease
Recipient
Rockefeller University, New York, NY
Award Amount
$778,367.00
Ceiling
$778,367.00
Awarded
February 23, 2026
Identifier
5R01AG076932-05
NIH funded research project to develop innovative single-cell genomic tools to study neurogenesis in aging and Alzheimer's disease, involving profiling millions of brain cells and spatial transcriptomics.
Description
The proposed research aims to develop state-of-the-art single-cell genomic approaches to understand the molecular mechanisms underlying neurogenesis dysregulation in aging and Alzheimer's disease. The project will create high-throughput, low-cost single-cell genomics techniques, such as sciNext1000 and sci-Div-seq, to profile millions of cells from human and mouse brains. Additionally, spatial transcriptomics will be employed to study cellular interactions within the neural stem niche.