NIH Reporter #1P01AI189645-01A1

Population variation in innate immune responses to pathogens

Research project funded by NIAID to study genetic factors influencing innate immune responses to pathogens using single cell technologies, aiming to understand variability in immune responses and susceptibility to infectious diseases.

Description

This project aims to identify genes and regulatory pathways that contribute to the variability of innate immune responses to five infectious pathogens, including bacteria, viruses, fungi, and parasites. It leverages single cell technologies to characterize inter-individual and inter-population variability in innate immune responses, map quantitative trait loci associated with variation in immune response, and evaluate the impact of natural selection on allele frequencies across populations. The work provides insights into the genetic basis of variation in immune responses and aims to identify those most at risk for infectious diseases and immune-related disorders.

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