Award
National Institute of General Medical Sciences 5R01GM151731-04
URIL tags for intracellular RNA tracking and RNP proximity labeling
Recipient
Ohio State University, Columbus, OH, United States
Award Amount
$364,674.00
Ceiling
$364,674.00
Awarded
June 23, 2026
Identifier
5R01GM151731-04
Dysregulated RNA biology is prominent in neurodegenerative diseases like ALS. The project aims to develop URIL-targeting tools for RNA and RNP studies, with potential applications in understanding ALS pathology.
Description
The project focuses on developing tools for RNA tracking and labeling, especially in the context of neurodegenerative diseases like ALS. It involves synthesis and evaluation of bifacial peptide nucleic acids (bPNAs) targeting URIL motifs. The research aims to probe disease-relevant RNP biology in patient-derived cells.