Award
National Institute on Aging 5R01AG054598-09
Astrocytes as governing pathological drivers of neurovascular dysfunction in AD
Recipient
Massachusetts General Hospital
Award Amount
$511,105.00
Ceiling
$511,105.00
Awarded
March 03, 2026
Identifier
5R01AG054598-09
Research grant awarded to study astrocytic calcium signaling's role in neurovascular dysfunction in Alzheimer's disease, aiming to identify therapeutic targets using advanced imaging.
Description
This project aims to investigate the role of astrocytic calcium signaling in neurovascular dysfunction in Alzheimer's disease (AD) using in vivo multiphoton microscopy. The hypothesis is that astrocytic calcium signaling pathophysiology is a major driver of neurovascular unit dysfunction and a potential therapeutic target.