Award
NIH Reporter #5I01BX004146-07
Impact of Obesity on Brain Immune Response and Cognition
Recipient
MINNEAPOLIS VA MEDICAL CENTER
Awarded
August 07, 2026
Identifier
5I01BX004146-07
Research project funded by Veterans Affairs studying the effects of obesity on brain immune response and cognition, focusing on neuroinflammation and Alzheimer's disease using mouse models, aiming to develop targeted therapies for cognitive impairment in Veterans.
Description
This project focuses on the impact of obesity on brain immune response and cognition, with specific emphasis on neuroinflammation, microglia, and Alzheimer's disease. It involves research using mouse models and diet interventions, with a focus on the FABP4-UCP2 axis in microglia. The project is funded by the Veterans Affairs and is associated with the Minneapolis VA Medical Center. The project aims to develop targeted therapies for cognitive impairment and neurodegenerative diseases, especially in underserved populations such as Veterans.