Award
NIH Reporter #1ZIAAG000359-04
Evaluating the Cell-Type Specificity and Cellular Targets of Senotherapuetic Compounds with Unknown Mechanisms
Recipient
National Institute on Aging (NIA)
Award Amount
$120,057.00
Ceiling
$120,057.00
Awarded
October 04, 2023
Identifier
1ZIAAG000359-04
This award funds a study on the mechanisms of senolytic flavonoids fisetin and quercetin, focusing on their cellular uptake and protein targets to understand their selective senolytic effects, with ongoing validation and future in vivo exploration.
Description
Research project investigating the senolytic activity of flavonoids such as fisetin and quercetin, their uptake mechanisms via OAT transporters, and identification of protein interactions mediating senolytic activity using chemoproteomic approaches.