Award
NIH Reporter #5R01AI176949-04
Ultra-long-acting Biodegradable and Tunable Polymeric Solid Implant for HIV Treatment Maintenance
Recipient
University of North Carolina at Chapel Hill, Department of Biomedical Engineering
Award Amount
$706,916.00
Ceiling
$706,916.00
Awarded
August 05, 2026
Identifier
5R01AI176949-04
The award funds the development of a biodegradable polymeric implant for sustained HIV treatment, aiming to improve adherence and efficacy through long-acting drug release.
Description
This project aims to develop and evaluate a biodegradable, highly tunable polymeric solid implant (PSI) for HIV treatment. The goal is to create an ultra-long-acting implant that provides sustained release of antiretroviral drugs, increasing adherence and efficacy in HIV management. The research involves designing small-sized implants (1-4 cm long) with high drug content (up to 85 wt%), utilizing modeling efforts for formulation development, and testing in macaque models infected with RT-SHIV to assess safety and efficacy.