# NIH Reporter #1R01DK147244-01

Phenotyping and Predicting Ultrafiltration Intolerance to Guide Transitions from Continuous to Intermittent Kidney Replacement Therapy

**Recipient:** University of Pennsylvania, Philadelphia, PA

**Award Amount:** $792,019.00
**Ceiling:** $792,019.00

**Awarded:** May 14, 2026

**Identifier:** 1R01DK147244-01

The award funds research to develop clinical risk scores and monitoring tools to guide transitions from continuous to intermittent kidney replacement therapy, improving patient outcomes by predicting ultrafiltration intolerance using machine learning and hemodynamic monitoring.

### Description

This project aims to develop predictive tools and risk scores to improve the safety and efficacy of dialysis modality transitions in critically ill patients, leveraging machine learning and novel monitoring technologies. It involves analysis of electronic health records and a prospective observational study to characterize ultrafiltration tolerance and guide dialysis transitions.

[View original record](https://reporter.nih.gov/search/0C83gI3MXki4-tEhFD4UKQ/project-details/11343278)