Award
NIH Reporter #4R00AA031313-03
RNA splicing regulation during alcohol withdrawal
Recipient
Loyola University Chicago, Maywood, IL, United States
Award Amount
$248,997.00
Ceiling
$248,997.00
Awarded
September 16, 2025
Identifier
4R00AA031313-03
This award funds research on how chronic alcohol exposure affects RNA splicing in the brain, particularly focusing on the splicing factor PCBP1, to understand molecular changes during alcohol withdrawal that contribute to negative affective states and to identify new treatment targets for AUD.
Description
The project investigates RNA splicing, focusing on the splicing factor PCBP1, as a mechanism by which chronic alcohol exposure and withdrawal lead to molecular alterations and negative affective states. The research aims to elucidate mechanisms underlying alcohol-induced changes in RNA splicing and its relevance for negative affective states during withdrawal, using advanced molecular, bioinformatic, and statistical approaches. The work will provide insights into molecular mechanisms, identify novel targets, and facilitate translational research for alcohol use disorder (AUD) treatment.