Award
National Institute of Allergy and Infectious Diseases 5R01AI182126-02
Gut Treg cells at the microbiome interface
Recipient
Harvard Medical School, Boston, MA
Award Amount
$588,753.00
Ceiling
$588,753.00
Awarded
December 02, 2025
Identifier
5R01AI182126-02
The NIH grant supports research on the role of FoxP3+ T regulatory cells in maintaining gut homeostasis and their interaction with the microbiome. The study focuses on Treg cell development, TCR specificity, and immune regulation influenced by microbes and food antigens during early life stages.
Description
This project explores the role of T regulatory cells in gut microbiota balance, TCR specificity, and immune regulation during critical postnatal periods. The research aims to understand how microbes and food antigens establish gut Treg phenotypes and TCR repertoires during postnatal and weaning periods, and during pTreg generation in adults.