Award
National Institute of Allergy and Infectious Diseases 5R03AI185599-02
Intracellular Vitamin D to Combat Instant Blood-Mediated Inflammatory Reaction
Recipient
Northwestern University, Chicago, IL, United States
Award Amount
$80,000.00
Ceiling
$80,000.00
Awarded
August 11, 2025
Identifier
5R03AI185599-02
This award funds research to develop a vitamin D nanotherapeutic to reduce inflammation and improve outcomes in islet transplantation for diabetes treatment.
Description
The project aims to assess a nanotherapeutic for the treatment of islet transplantation associated instant-blood-mediated inflammatory reaction (IBMIR). It involves developing a targeted vitamin D delivery system using vesicular polymeric nanocarriers (polymersomes, PS) encapsulating vitamin D3 (aVD-PS) to enhance intracellular delivery, reduce inflammatory markers, and mitigate oxidative stress, thrombosis, and inflammation during islet transplantation.